We are seeking a highly motivated postdoctoral scientist to undertake research in tumor immunology to investigate novel therapeutic targets for cancer immunotherapy and translation to the clinic.
Research focus
To investigate molecular and cellular mechanisms of anti-tumor immunity and test novel immunotherapy targets using cutting-edge genomic and immunological tools and mouse models.
Requirements
· Ph.D. or MD/PhD in immunology
· Experience in murine work and in vivo/functional experiments using mouse models
· Experience with tumor models, brain tumor models, leukemia models are desirable
Publications to review:
1. Upadhye A, Meza Landeros KE, Ramírez-Suástegui C, Schmiedel BJ, Woo E, Chee SJ, Malicki D, Coufal NG, Gonda D, Levy ML, Greenbaum JA, Seumois G, Crawford J, Roberts WD, Schoenberger SP, Cheroutre H, Ottensmeier CH, Vijayanand P, Ganesan AP. Intra-tumoral T cells in pediatric brain tumors display clonal expansion and effector properties. Nat Cancer. 2024 . Epub 2024/01/17. doi: 10.1038/s43018-023-00706-9. PubMed PMID: 38228835.
2. Clarke J, Panwar B, Madrigal A, Singh D, Gujar R, Wood O, Chee SJ, Eschweiler S, King EV, Awad AS, Hanley CJ, McCann KJ, Bhattacharyya S, Woo E, Alzetani A, Seumois G, Thomas GJ, Ganesan AP, Friedmann PS, Sanchez-Elsner T, Ay F, Ottensmeier CH, Vijayanand P. Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer . J Exp Med. 2019 Sep 2 ;216(9):2128- 2149. doi: 10.1084/jem.20190249. Epub 2019 Jun 21.
3. Ganesan AP, Clarke J, Wood O, Garrido-Martin EM, Chee SJ, Mellows T, Samaniego-Castruita D, Singh D, Seumois G, Alzetani A, Woo E, Friedmann PS, King EV, Thomas GJ, Sanchez-Elsner T, Vijayanand P, Ottensmeier CH. Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer. Nature Immunology. 2017 Jun 19 . doi:10.1038/ni.3775
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